Oxidative cleavage of vicinal diols: IBX can do what Dess-Martin periodinane (DMP) can.
نویسندگان
چکیده
The fact that IBX exhibits reactivity akin to DMP is demonstrated from the results observed with strained and sterically hindered syn 1,2-diols, which undergo oxidative cleavage via a 12-I-5 spirobicyclic periodinane. The use of TFA, a protonating solvent, promotes the formation of the 12-I-5 intermediate for 1,2-diols of all types (sec,sec, sec,tert and tert,tert), leading to efficient oxidative fragmentation.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 5 5 شماره
صفحات -
تاریخ انتشار 2007